A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues
نویسندگان
چکیده
For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are known for their bioactivity, a chemoselective procedure has been developed starting from m-(chlorosulfonyl)benzoyl chloride. Although a chemoselective process in batch was already reported, a continuous-flow process reveals an increased selectivity at higher temperatures and without catalysts. In total, 15 analogues were synthesized, using similar conditions, with yields ranging between 65 and 99%. This is the first automated and chemoselective synthesis of m-sulfamoylbenzamide analogues.
منابع مشابه
Chemoselective Synthesis of Pentaerythritol Diacetals Catalyzed by CuO-CeO2 Nanocomposite under Solvent-free Conditions
CuO-CeO2 nanocomposite is reported as a green recyclable catalyst for the chemoselective synthesis of pentaerythritol diacetals from aromatic aldehydes under solvent-free conditions. The catalyst was synthesized by co-precipitation method and characterized by XRD, BET specific surface area, FESEM and EDS analysis. This procedure provides some advantages such as simple work-up, clean procedure, ...
متن کاملSynthesis and Applicationof New Fluorescein Analogues
In this project, new derivatives of fluorescein were synthesized using the reaction of maleic anhydride and saccharin with phenol derivatives in the presence of ZnCl2, and their structures were elucidated by UV, IR, and NMR spectroscopy. Fluorimetry studies showed that, the synthesized compounds can be utilized as fluorescent agents, and their efficiencies were dependent on pH of solution. Acco...
متن کاملNanocatalyst of ZnO Supported Copper Oxide Catalyzed Chemoselective Synthesis of 1,1-diacetates
In this research, a metal oxide nanocatalyst of ZnO supported copper oxide is reported as a highly efficient recyclable catalyst for the chemoselective synthesis of 1,1-diacetates. The catalyst was synthesized by co-precipitation method and characterized by XRD, BET specific surface area, ESEM, EDS and TEM analysis. A wide range of aldehydes, including aromatic and aliphatic aldehydes were conv...
متن کاملSynthesis and study of effects of new 4-chloro – amodiaquine analogues against two resistant and sensitive forms to chloroquine Plasmodium Falciparum, in vitro
Background: Resistance to chloroquine (CQ) in Plasmodium falciparum malaria has become a major health concern of the developing countries.This resistance has prompted a re-examination of the pharmacology of alternative antimalarials that may be effective against resistant strains. Amodiaquine (AQ) is a 4-aminoquinoline antimalarial which is effective against many chloroquine-resistant strains o...
متن کاملAn Efficient Method for the Chemoselective Synthesis of Germinal Diacetates from Aromatic and Heteroaromatic Aldehydes Using Nano Silica Chloride
In this investigation, Nano silica chloride (nano SiO2Cl) has been found to be efficient, chemoselective and recyclable catalyst for facile and simple synthesis of germinal diacetates from aromatic and heteroaromatic aldehydes in shorter reaction durations. The products were obtained in high to excellent yields. This work consistently has the advantages of excellent yields, short reaction time,...
متن کامل